缬氨酸
亮氨酸
异亮氨酸
氨基酸
新陈代谢
内分泌学
肥胖
内科学
芳香族氨基酸
化学
生物化学
生物
医学
作者
David G. Le Couteur,Samantha M. Solon‐Biet,Victoria C. Cogger,Rosilene V. Ribeiro,Rafael de Cabo,David Raubenheimer,Gregory J. Cooney,Stephen J. Simpson
标识
DOI:10.1016/j.arr.2020.101198
摘要
Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies report apparently inconsistent conclusions about the relationships between blood levels of BCAAs or dietary manipulation of BCAAs with age-related changes in body composition, sarcopenia, obesity, insulin and glucose metabolism, and aging biology itself. These divergent results can be resolved by consideration of the role of BCAAs as signalling molecules and the bidirectional mechanistic relationship between BCAAs and some aging phenotypes. The effects of BCAAs are also influenced by the background nutritional composition such as macronutrient ratios and imbalance with other amino acids. Understanding the interaction between BCAAs and other components of the diet may provide new opportunities for influencing age-related outcomes through manipulation of dietary BCAAs together with titration of macronutrient ratios and other amino acids.
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