pp65 antigen and human cytomegalovirus infection

HCMV infection can cause hepatopathy, pneumonia, diarrhea, thrombocytopenic purpura, and sensorineural hearing loss(SNHL), with high morbility and mortality.pp65(phosphoprotein 65), a major constitutive protein of virion, is closely associated with viral gene expression, immune evasion and cell metabolism.pp65 antigenemia level has positive correlation with clinical symptom, which can guide the preemptive therapy and improve prognosis, is considered as one of the golden standard methods of active cytomegalovirus infection.In this paper, the pp65 protein properties, pathogenesis, application in diagnosis and prevention are reviewed. Key words: Human cytomegalovirus; Phosphoprotein 65; Antigenemia