黄芩苷
金黄色葡萄球菌
体内
微生物学
体外
最小抑制浓度
抗生素
耐甲氧西林金黄色葡萄球菌
万古霉素
毒力
抗菌剂
化学
生物
细菌
生物化学
基因
高效液相色谱法
生物技术
遗传学
色谱法
作者
Shouping Zhang,Bin Hu,Jingfei Xu,Qiuxuan Ren,Zhichen Wang,Sanhu Wang,Yongjun Dong,Guoyu Yang
标识
DOI:10.1016/j.micpath.2019.103899
摘要
A Staphylococcus aureus (S.aureus) was isolated from pigs suffered in pneumonia that can't be cured by antibiotic such as methicillin and vancomycin. It was demonstrated that baicalin, an active natural compound extracted from the traditional Chinese medicinal, possess antimicrobial activity. In the present study, we evaluate it efficacy in vitro and vivo against this isolated methicillin-resistant S.aureus (MRSA). Our findings demonstrated that baicalin can inhibit S. aureus growth in a dose-dependent manner and attenuate the biofilm formation. Scanning electron microscopies showed that cell membrane was damaged and accompany with contents leaks after treated with high concentration of baicalin. In addition, baicalin exerted inhibitory effects on the expression of S.aureus virulence-related factors. Moreover, baicalin treated mice had enhanced survival after a lethal dose of S.aureus infection compared with untreated mice. Simultaneously, the pathological tissue damage and bacterium burden were decrease in baicalin treated mice. These data demonstrated that baicalin displayed a high effectiveness in vitro and vivo against MRSA infection, suggesting that baicalin may potentially be used to treat MRSA infection.
科研通智能强力驱动
Strongly Powered by AbleSci AI