Analysis of the clinical features and prognostic factors of pulm- onary mucinous carcinoma

Objective The aim of the present study was to explore the clinical features of Pulmonary mueoepidermoid carcinoma (PMEC) and to analysis the tumor's treatment and prognosis factors, to improve the awareness of the disease and the level of diagnosis and treatments. Methods To collect nearly 5 years of Fuzhou general hospital of Nanjing military region which were diagnosed with PMEC underwent 9 cases and the last decade of 292 literature cases collected from CNKI. The patients were classified into low-grade group and high-grade group, based on histological grades. The clinical data, radiological manifestation, pathological findings, treatment strategy, and prognoses of all patients were analyzed retrospectively. Results Surgical treatment were 198 cases, 34 cases from these cases accepted postoperative radiation or chemotherapy, Comprehensive radiation and chemotherapy included 56 cases, 6 patients by targeting therapy, and 41 cases give up treatment; the 5 year survival rate was 43.6%. High-grade PMEC often with high malignant, and was more common in patient with advanced tumor-node-metastasis (TNM) stage and lymph node metastasis respectively(all P<0.000 1). Log-rank test analysis showed that age, pathological grade, lymph node metastasis and TNM stage were correlated with the survival of PMEC patients. In the forward conditional Cox regression model, lymph node metastasis was the most important influencing factors (HR, 0.358, 95%CI, 0.114~0.265, P<0.000 1). Conclusions Lung mucous epidermoid carcinoma is a rare tumor, prognosis is influenced by many factors, and lymph node metastasis is one of the most important influencing factors. The surgical treatment is still the only effective means at present. And the curative effect of radiation and chemotherapy and there is no unified conclusion, targeted therapy is a promising treatment. Key words: Mucinous carcinoma of the lung; Clinical features; Chest CT manifestations; Prognostic factors