催化作用
免疫原性细胞死亡
化学
氧化应激
免疫疗法
过氧化物酶
癌症研究
免疫系统
酶
肿瘤微环境
葡萄糖氧化酶
癌症免疫疗法
人工酶
氧化酶试验
生物化学
医学
免疫学
作者
Mei Wen,Jiang Ouyang,Chuan‐Wan Wei,Hui Li,Wansong Chen,You‐Nian Liu
标识
DOI:10.1002/anie.201909729
摘要
Abstract Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems is to build antitumor immunity. However, immunotherapeutic efficacy is highly impeded by the immunosuppressive state of the tumors. Here a new strategy is presented, catalytic immunotherapy based on artificial enzymes. Cu 2− x Te nanoparticles exhibit tunable enzyme‐mimicking activity (including glutathione oxidase and peroxidase) under near‐infrared‐II (NIR‐II) light. The cascade reactions catalyzed by the Cu 2− x Te artificial enzyme gradually elevates intratumor oxidative stress to induce immunogenic cell death. Meanwhile, the continuously generated oxidative stress by the Cu 2− x Te artificial enzyme reverses the immunosuppressive tumor microenvironment, and boosts antitumor immune responses to eradicate both primary and distant metastatic tumors. Moreover, immunological memory effect is successfully acquired after treatment with the Cu 2− x Te artificial enzyme to suppress tumor relapse.
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