翻转酶
自磷酸化
ATP水解
ATP酶
三磷酸腺苷
化学
内膜
型三磷酸腺脢
生物物理学
细胞生物学
细菌外膜
生物化学
膜
生物
酶
磷脂酰丝氨酸
蛋白激酶A
磷脂
基因
大肠杆菌
作者
Masahiro Hiraizumi,Keitaro Yamashita,Tomohiro Nishizawa,Osamu Nureki
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-09-13
卷期号:365 (6458): 1149-1155
被引量:130
标识
DOI:10.1126/science.aay3353
摘要
Flipping a lipid The membranes of eukaryotic cells have different lipid compositions in their inner and outer leaflets. Enzymes known as flippases and floppases use the energy from adenosine triphosphate (ATP) hydrolysis to translocate lipids against a concentration gradient from the outer to inner or inner to outer leaflets, respectively. Flippases are P4-type ATPases that are important in processes such as membrane trafficking, signaling, and apoptosis. Hiraizumi et al. report the cryo–electron microscopy structure of six intermediates of the human flippase ATP8A1 bound to the partner protein it requires for function, CDC50. ATP binding and autophosphorylation of ATP8A1 drive a cycle of conformations in which lipids bind differently, powering translocation. Science , this issue p. 1149
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