铁载体
化学
细菌
特洛伊木马
螯合作用
异羟肟酸
抗菌活性
组合化学
特洛伊木马
生物化学
有机化学
生物
操作系统
基因
遗传学
计算机科学
计算机安全
作者
Danah Al Shaer,Othman Al Musaimi,Beatriz G. de la Torre,Fernando Alberício
标识
DOI:10.1016/j.ejmech.2020.112791
摘要
Hydroxamic acids are an important class of molecules, in particular because of their metal-chelating ability. Microorganisms, including pathogenic bacteria, use hydroxamate-based entities (siderophores), among others, to acquire Fe (III). The "Trojan horse" strategy exploits the need of bacteria for this metal by using Fe (III) active transporters to carry antibacterial or bactericidal moieties into the bacterial cell. Many natural Trojan horses (sideromycins) are derived from hydroxamic acids, thereby reflecting their potency. Various artificial sideromycins and their antibacterial activities have been reported. This review discusses the structural aspects of the hydroxamate-siderophores isolated in the last two decades, the chemical synthesis of their building blocks, their binding affinity towards Fe (III), and their application as Trojan horses (weaknesses and strengths).
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