Eco-friendly C-3 Selenation of Imidazo[1,2-a]pyridines in Ionic Liquid

An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1,2-a]pyridines with vorious organoselenides has been developed, gaving the desired products in moderate to excellent yields.Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism.The features with relative green reaction conditions, broad substrate scope, and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.