炎症性肠病
结肠炎
医学
胃肠病学
免疫学
内科学
生物
疾病
作者
Xiaomeng Wang,Tong Zhao,Xiang Cheng,Ning Guo,Ling‐Ling Zhu,Ming Shi,Kui-Wu Wu
出处
期刊:PubMed
日期:2018-01-08
卷期号:34 (1): 4-7
被引量:2
标识
DOI:10.12047/j.cjap.5567.2018.002
摘要
To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD).Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group. DSS-induced CHL1(+/+) group and DSS-induced CHL1(-/-)group were fed with 1.5% DSS for 7 days, and then drinking distilled water for 2 days. CHL1(+/+) group and CHL1(-/-) group as control group were fed with distilled water for 9 days. The changes of weight, survival, fecal blood and the change of colon length in this study were observed.On the 7th day, the weight of DSS-induced CHL1(-/-) group were reduced significantly, and DSS-induced CHL1(-/-) group had extreme mortality on the 9th day. The fecal blood of DSS-induced CHL1(-/-) group also had higher score than that of DSS-induced CHL1(+/+) group. In the DSS-induced CHL1(-/-) group,the length of colon was shortened obviously.The loss of CHL1 aggravates the development of IBD.
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