细胞外基质
嘌呤能受体
细胞生物学
神经科学
胶质增生
神经周围网
功能(生物学)
再生(生物学)
生物
基质(化学分析)
中枢神经系统
细胞外
化学
色谱法
作者
Mariachiara Zuccarini,Marzia Carluccio,Sihana Ziberi,Patricia Giuliani,Giorgio Caretta,Costanza Conti,Renata Ciccarelli,Patrizia Di Iorio
出处
期刊:PubMed
日期:2018-12-24
卷期号:32 (6): 1349-1353
被引量:1
摘要
Exracellular matrix (ECM) consists of a plethora of proteins and polysaccharides, which aggregate into an organized network connected to the surface of the producing cells. It is structurally and functionally present in all components of tissues and organs and represents the substrate on which cells adhere, migrate, proliferate and differentiate, influencing their survival, shape and function. In response to acute (trauma) or chronic (degenerative) insults, brain ECM modifies its composition and function, actively contributing to "scar forming" gliosis or tissue degeneration/remodelling. Moreover, morphological changes in dendritic spines associated with extracellular matrix remodeling play key roles in rewiring synaptic circuitry pertinent to memory formation. In the present report, we collected the main acquisitions on the functional interplay between ECM alterations and the adenine-/guaninebased purine system with particular regard on how purine compounds and their respective receptors may affect and be affected by changes of the cerebral ECM.
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