癌细胞
癌症
糖酵解
磷酸戊糖途径
生物
谷氨酰胺
代谢途径
谷氨酰胺分解
厌氧糖酵解
癌症研究
生物化学
新陈代谢
氧化磷酸化
细胞生物学
氨基酸
遗传学
作者
Pegah Farhadi,Reza Yarani,Sadat Dokaneheifard,Kamran Mansouri
出处
期刊:Tumor Biology
[SAGE]
日期:2020-10-01
卷期号:42 (10): 101042832096528-101042832096528
被引量:63
标识
DOI:10.1177/1010428320965284
摘要
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic glycolysis and other cancer-specific metabolism changes are known as the cancer hallmarks, distinct cancer cells from normal cells. Therefore, these tumor-specific characteristics receive the limelight as targets for cancer therapy. Glutamine, serine, and fatty acid oxidation together with 5-lipoxygenase are main pathways that have attracted lots of attention for cancer therapy. In this review, we not only discuss different tumor metabolism aspects but also discuss the metabolism roles in the promotion of cancer cells at different stages and their difference with normal cells. Besides, we dissect the inhibitors potential in blocking the main metabolic pathways to introduce the effective and non-effective inhibitors in the field.
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