共核细胞病
α-突触核蛋白
路易氏体型失智症
路易体
蛋白质折叠
生物物理学
化学
蛋白质聚集
成核
帕金森病
细胞生物学
纤维
淀粉样蛋白(真菌学)
神经科学
生物
痴呆
疾病
医学
病理
有机化学
作者
A. L. Schwarzman,Konstantin Senkevich,Emil Anton,С. Н. Пчелина
出处
期刊:Molekulârnaâ biologiâ
[Pleiades Publishing]
日期:2019-01-01
卷期号:53 (3): 380-387
被引量:3
标识
DOI:10.1134/s0026898419030182
摘要
The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and its various conformers are discussed. It is shown that alpha-synuclein may be transferred between cells by prion-like propagation. Similarly to other prions, alpha-synuclein aggregation develops from the initial lag-phase (nucleation) to the subsequent growth phase (elongation), and to the stationary phase where the aggregates and monomers exist in equilibrium. Similarly to prions, alpha-synuclein undergoes conformational changes from an alpha-helix to its beta-folded structure. However, there is currently no evidence that alpha-synuclein-dependent PD can be transmitted from person-to-person. This review describes the prion properties of alpha-synuclein, possible ways of its intercellular propagation, and novel approaches to PD diagnostics.
科研通智能强力驱动
Strongly Powered by AbleSci AI