苯拉唑马布
医学
慢性阻塞性肺病
肺病
安慰剂
内科学
重症监护医学
临床试验
自然史
嗜酸性粒细胞
作者
Gerard J. Criner,Bartolomé R. Celli,Christopher E. Brightling,Àlvar Agustí,Alberto Papi,Dave Singh,Don D. Sin,Claus Vogelmeier,Frank C. Sciurba,Mona Bafadhel,Vibeke Backer,Motokazu Kato,Alejandra Ramírez‐Venegas,Yu-Feng Wei,Leif Bjermer,Vivian H. Shih,Maria Jison,Sean O’Quinn,Natalya Makulova,Paul Newbold
标识
DOI:10.1056/nejmoa1905248
摘要
Add-on benralizumab was not associated with a lower annualized rate of COPD exacerbations than placebo among patients with moderate to very severe COPD, a history of frequent moderate or severe exacerbations, and blood eosinophil counts of 220 per cubic millimeter or greater (Funded by AstraZeneca [GALATHEA and TERRANOVA] and Kyowa Hakko Kirin [GALATHEA]; GALATHEA and TERRANOVA ClinicalTrials.gov numbers, NCT02138916 and NCT02155660.).
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