炎症体
化学
受体
ATP水解
细胞生物学
小分子
生物化学
酶
生物
ATP酶
作者
Rebecca C. Coll,J. R. Hill,Christopher J. Day,Alina Zamoshnikova,Dave Boucher,Nicholas L. Massey,Jessica L. Chitty,James A. Fraser,Michael P. Jennings,Avril A. B. Robertson,Kate Schroder
标识
DOI:10.1038/s41589-019-0277-7
摘要
Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation.
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