低血糖
胰岛素
葡萄糖转运蛋白
胰岛素类似物
糖尿病
胰岛素释放
内分泌学
内科学
体内
内生
运输机
血糖调节
碳水化合物代谢
医学
药理学
化学
1型糖尿病
生物
生物化学
人胰岛素
生物技术
基因
作者
Jinqiang Wang,Jicheng Yu,Yuqi Zhang,Anna R. Kahkoska,Zejun Wang,Jun Fang,Julian P. Whitelegge,Song Li,John B. Buse,Zhen Gu
标识
DOI:10.1073/pnas.1901967116
摘要
Significance Glucose-responsive insulin analogs or delivery systems are desirable for enhancing health and improving quality of life of people with diabetes. We describe here a simple strategy to engineer a long-acting insulin analog, which can establish an endogenous Glut-associated delivery reservoir of insulin that can modulate glucose metabolism in a blood glucose-dependent manner. Importantly, after subcutaneous injection, in vivo blood glucose regulation was validated in a type 1 diabetic mouse model with negligible hypoglycemia.
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