生物标志物
多囊卵巢
铁蛋白
荟萃分析
医学
内科学
生物
内分泌学
生物信息学
遗传学
胰岛素抵抗
胰岛素
作者
Raphael Enrique Tiongco,N Rivera,Benjie Clemente,Dianne Dizon,Crizelda Salita,Maria Ruth Pineda-Cortel
出处
期刊:Biomarkers
[Informa]
日期:2019-05-27
卷期号:24 (5): 484-491
被引量:5
标识
DOI:10.1080/1354750x.2019.1620335
摘要
Objective: In this study, we investigated about the potential of serum ferritin as a complementary diagnostic biomarker of polycystic ovarian syndrome (PCOS) by performing a meta-analysis of existing literature. Materials and methods: Eleven studies written in English were retrieved up to 30 June 2018. Data were extracted from the selected studies by two of the authors and was subjected to statistical analysis. Levels of serum ferritin were compared between women with PCOS and controls using the standardized mean difference (SMD) and 95% confidence interval (CI). Subgroup analysis was also performed and stratified by ethnicity (Asians versus Caucasians). Results: Overall post-outlier outcomes indicated that elevated serum ferritin is strongly associated with PCOS (SMD: 0.52; 95% CI: 0.40-0.64; PA = 10-5). Subgroup analysis by ethnicity showed no significant difference between Asian and Caucasian population. Post-outlier receiving operations characteristics curve were plotted and showed that values for serum ferritin showed good potential in discriminating patients with and without PCOS (AUC = 0.827, p = 0.006). Conclusion: Our findings suggest that high serum ferritin level is significantly associated with PCOS and its potential as a biomarker is evident in its high diagnostic accuracy. However, additional studies are needed to confirm our claims.
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