A8062 Effects of long-term high-salt diet on blood pressure variability in Wistar rats

Objectives: To observe the effects of long-term high-salt diet on blood pressure variability in Wistar rats. Methods: The 53 male Wistar rats were randomly divided into control group (containing 0.5% NaCl, n = 12) and 8% high-salt group (containing 8% NaCl, n = 41), Both water and food were supplied ad libitum for 24 weeks. Tail systolic blood pressure was monitored by tail-cuff artery pressure-measuring instrument, the tail artery pressure of the rats was respectively determined before the experiment (0 week), in the 3rd, 5th, 6th, 7th, 9th, 11th, 13th, 15th, 17th, 19th, 21st, 23rd, 24th week. According to the blood pressure levels, the 8% high-salt group were divided into high-salt normal blood pressure group (HSN group, n = 7) and high-salt hypertension group (HSH group, n = 34), all groups of short-term BPV and long-term BPV were calculated after the end of the experiment. Results: Compared with control group, the blood pressure, short-term systolic blood pressure variability (SBPV), short-term standard deviation of diastolic blood pressure (DSD), long-term SBPV and diastolic blood pressure variability (DBPV) were continuously increased in 8% high-salt group (P < 0.05). The long-term SBPV was increased in HSN group (P < 0.05), the blood pressure, short-term SBPV, long-term SBPV, short-term DSD, long-term DBPV were increased in HSH group (P < 0.05). Compared with HSN group, the blood pressure, long-term SBPV and long-term DBPV were increased in HSH group (P < 0.05). Conclusion: Long-term high-salt diet may induce increases the long-term SBPV, long-term DBPV, and earlier than the rise of blood pressure in high-salt hypertension group. The long-term SBPV is increased in high-salt normal blood pressure group.