生物相容性
化学
药品
琼脂
药物输送
细菌纤维素
琼脂扩散试验
微生物学
药理学
纤维素
牙科
细菌
医学
生物化学
有机化学
生物
基因
大肠杆菌
遗传学
作者
Peter Weyell,Uwe Beekmann,Christine Küpper,Marco Dederichs,Jana Thamm,Dagmar Fischer,Dana Kralisch
标识
DOI:10.1016/j.carbpol.2018.11.061
摘要
Bacterial cellulose (BC) has shown high potential as innovative wound dressing and drug delivery system. Bringing both together, drug-loaded BC was investigated for applications in dental therapies such as dental extraction or mucosal transplantation. Both applications would benefit from a material which degrades under physiological conditions, and from an antibiotic environment. Consequently, periodate-oxidation of BC was investigated to facilitate modified degradation behaviour. A periodate concentration of 0.14 mol/L at ϑ = 25 °C and t = 8 h resulted in a material loss of <10%, but at the same time a sufficient degree of degradation. Additionally, native and oxidised BC loaded with doxycycline was tested for prophylaxis against infection. An in vitro-toxicity test (MTT assay) provided a first confirmation of biocompatibility, whereas agar diffusion tests proved antibiotic efficiency against pathogenic oral bacteria. Release studies of the drug from native and oxidised BC confirmed a comparative biphasic release behaviour.
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