聚乙烯吡咯烷酮
伤口愈合
聚乙二醇
伤口敷料
抗菌活性
丙烯酰胺
聚合物
材料科学
阳离子聚合
PEG比率
自愈水凝胶
化学
复合材料
高分子化学
细菌
外科
有机化学
共聚物
医学
生物
遗传学
财务
经济
作者
Li Wang,Jihui Wang,Lin Li,Longquan Xu,Nuan Feng,Yi Wang,Fei Xu,Jing Tian,Yao Li
标识
DOI:10.1016/j.cej.2019.04.107
摘要
As materials for the promotion of wound healing, hydrogel dressings must be usable for a long time or under extreme conditions. Traditional hydrogel dressings are often used for a short time mainly due to water loss at high temperature or water freezing at low temperature. This paper reports a facile approach to synthesize a novel antibacterial hydrogel wound dressing based on polyvinylpyrrolidone acrylamide 1-vinyl-3-butylimidazolium and polyethylene glycol dimethacrylate via one-pot method. This hydrogel has cationic groups in the polymer chains and exhibits effective antibacterial and antifungal activity. Furthermore, this hydrogel has anti-freezing, non-drying, and self-healing properties because of its unique molecular structure. Results of wound closure and histopathological examinations demonstrate that the fabricated hydrogel wound dressing effectively promotes the wound healing process in a full-thickness skin defect model. Therefore, this antibacterial hydrogel may be used as a wound healing dressing, even under extreme conditions.
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