肿瘤微环境
免疫系统
生物
肿瘤进展
趋化因子
髓源性抑制细胞
癌细胞
间质细胞
先天性淋巴细胞
癌症
先天免疫系统
重编程
癌症研究
免疫学
细胞
抑制器
遗传学
作者
Dominique C. Hinshaw,Lalita A. Shevde
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2019-09-13
卷期号:79 (18): 4557-4566
被引量:1830
标识
DOI:10.1158/0008-5472.can-18-3962
摘要
Abstract Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors. This results in a reprogramming of the surrounding cells, enabling them to play a determinative role in tumor survival and progression. Immune cells are important constituents of the tumor stroma and critically take part in this process. Growing evidence suggests that the innate immune cells (macrophages, neutrophils, dendritic cells, innate lymphoid cells, myeloid-derived suppressor cells, and natural killer cells) as well as adaptive immune cells (T cells and B cells) contribute to tumor progression when present in the tumor microenvironment (TME). Cross-talk between cancer cells and the proximal immune cells ultimately results in an environment that fosters tumor growth and metastasis. Understanding the nature of this dialog will allow for improved therapeutics that simultaneously target multiple components of the TME, increasing the likelihood of favorable patient outcomes.
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