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Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis

溃疡性结肠炎 医学 胃肠病学 尿酸 炎症性肠病 内科学 肌酐 克罗恩病 结肠炎 人口 疾病 环境卫生
作者
Feng Zhu,Dengyu Feng,Tenghui Zhang,Lili Gu,Weiming Zhu,Zhen Guo,Yi Li,Nan Lü,Jianfeng Gong,Ning Li
出处
期刊:Journal of Gastroenterology and Hepatology [Wiley]
卷期号:34 (1): 154-161 被引量:24
标识
DOI:10.1111/jgh.14356
摘要

Patients with inflammatory bowel disease (IBD) have higher incidence of developing nephrolithiasis. Increased uric acid production induced by Saccharomyces cerevisiae exacerbates colitis in mice. We aimed to evaluate the association between serum uric acid level and disease activity in IBD population.Four hundred and thirty-five patients enrolled in Jinling Hospital from January 1, 2015 to August 31, 2017 were included in the retrospective study. Clinical parameters were collected and compared with non-IBD matched controls (n = 51). Serum uric acid to creatinine ratio (UA/Cr) was used as a biomarker for uric acid metabolism. Sixty-five active IBD patients were longitudinally studied to investigate the UA/Cr before and after therapy. Linear mixed models were estimated for Crohn's disease (CD) group to explore the relationship between UA/Cr and other parameters.Uric acid to creatinine ratio was significantly correlated with Crohn's disease activity index (ρ = 0.184, P = 0.002) and Harvey Bradshaw index (ρ = 0.154, P = 0.010) and C-reactive protein (ρ = 0.591, P < 0.001) in CD group. Colonic CD and anti-Saccharomyces cerevisiae antibody (ASCA) positive CD had an increased UA/Cr compared with L1, L3, and ASCA negative CD (P = 0.027, P = 0.0013, and P = 0.043, respectively). A significant decrease in UA/Cr was observed after induction therapy in active CD (P = 0.0002) but not in ulcerative colitis (P = 0.076).Uric acid to creatinine ratio correlated with disease activity in CD. Colonic CD and ASCA positive CD had an increased UA/Cr. Effective treatment for CD patients lowered UA/Cr. Uric acid metabolism might be a novel aspect to investigate disease activity of IBD.
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