肠道菌群
微生物学
多糖
细菌
海参
脂多糖
生物化学
生物膜
解聚
生物
化学
免疫学
遗传学
生态学
有机化学
作者
Zhenjun Zhu,Beiwei Zhu,Yujiao Sun,Chunqing Ai,Sufeng Wu,Linlin Wang,Shuang Song,Xiaoling Liu
标识
DOI:10.1016/j.ijbiomac.2018.08.098
摘要
Sulfated polysaccharide from sea cucumber (SCSP) has been demonstrated with various health effects, the mechanism of which, however, remains poorly understood. This study aimed to investigate the possible mechanism exhibited by gut microbiota in response to SCSP. BALB/c mice were fed diets supplemented with SCSP and depolymerized SCSP (d-SCSP) for 42 days. The microbiota composition, short chain fatty acids (SCFAs), lipopolysaccharide-binding protein (LBP), body weight and gut tissue index were analyzed. Results revealed that both SCSP and d-SCSP positively regulated the gut microbiota as indicated by the enriched microbiota diversity, SCFA-producing bacteria and sulfide-degrading bacteria, and decreased harmful bacteria. Moreover, SCSP and d-SCSP not only significantly improved the levels of microbial metabolites including SCFAs and LBP, but also effectively adjusted body weight and gut tissue index. The microbial metabolites were identified to strongly correlate with the growth performance using Pearson's correlation coefficient. We further showed that the modulating effect of SCSP on the gut microbiota was altered by free-radical depolymerization, while the microbial metabolites and related growth performance were not. These findings suggest that SCSP can be used as a gut microbiota manipulator for health promotion and alter the gut microbiota in a molecular weight (Mw) dependent manner.
科研通智能强力驱动
Strongly Powered by AbleSci AI