Facile synthesis of alpha-phase strontium pyrophosphate incorporated with polypyrrole composite for the electrochemical detection of antipsychotic drug chlorpromazine

• SPO incorporated with PPy composite was synthesized by the simple sonochemical method. • The excellent electrocatalytic response was exploited for the sensing of antipsychotic drug CPZ. • The WLR, low LOD, good selectivity, and high stability were achieved towards CPZ detection. • The feasibility of the fabricated electrode was applied to CPZ in human samples with satisfactory results. The probable electrochemical sensing of CPZ at the SPO/PPy/SPCE. The ceramic material alpha-phase strontium pyrophosphate (α-Sr 2 P 2 O 7 , SPO) was synthesized via the coprecipitation technique and the polypyrrole (PPy) was prepared through the chemical oxidation technique. The SPO incorporated with PPy composite was prepared using the sonochemical treatment which is applied for the electrochemical oxidation of antipsychotic drug chlorpromazine (CPZ). The SPO/PPy is engineered through electrostatic interaction of positively charged PPy and negatively charged SPO. This specific property enhances the conductivity and catalytic activity of the modified electrode. The resultant SPO/PPy was examined using various characterization techniques and the electrochemical activity of SPO/PPy modified screen-printed carbon electrode (SPCE) was assessed through electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) methods. The constructed SPO/PPy/SPCE has broad linearity of 0.8–1207 µM with the lowest detection limit (LOD) of 0.069 µM, and a sensitivity of 0.592 µA µM –1 cm –2 towards the detection of CPZ. Further, the CPZ sensor revealed good specificity, cyclic stability, and precision. The real-time monitoring of CPZ was estimated in human urine and serum samples with good recoveries.