Association of Habitual Preoperative Dietary Fiber Intake With Complications After Colorectal Cancer Surgery

医学 结直肠癌 四分位间距 内科学 队列研究 腹部外科 癌症 外科
作者
Dieuwertje E. Kok,Melissa Arron,Tess Huibregtse,Flip M. Kruyt,Dirk Jan Bac,Henk K. van Halteren,Ewout A. Kouwenhoven,Evertine Wesselink,Renate M. Winkels,Fränzel J.B. van Duijnhoven,Johannes H. W. de Wilt,Ellen Kampman
出处
期刊:JAMA Surgery [American Medical Association]
卷期号:156 (9): 827-827 被引量:8
标识
DOI:10.1001/jamasurg.2021.2311
摘要

Importance

Postoperative complications are associated with increased morbidity and mortality among patients with colorectal cancer. As a modifiable factor associated with gut health, dietary fiber intake is of interest with regard to the risk of complications after surgery for colorectal cancer.

Objective

To examine the association between preoperative dietary fiber intake and risk of complications after surgery for colorectal cancer.

Design, Setting, and Participants

This cohort study used data from the Colorectal Longitudinal, Observational Study on Nutritional and Lifestyle Factors (COLON) study, which recruited adult patients with colorectal cancer at any stage at diagnosis from 11 hospitals in the Netherlands between August 2010 and December 2017. The present study included patients with stage I to IV colorectal cancer who underwent elective abdominal surgery. Data were analyzed between December 2019 and September 2020.

Exposures

Habitual dietary fiber intake was assessed at diagnosis using a 204-item food frequency questionnaire.

Main Outcomes and Measures

Any complications, surgical complications, and anastomotic leakage occurring during the 30 days after surgery for colorectal cancer. The association between fiber intake and risk of postoperative complications was assessed using logistic regression analyses. Additional analyses stratified by sex, tumor location, and fiber source were performed.

Results

Among the 1399 patients included in the analysis, the median age at inclusion was 66 years (interquartile range, 61-72 years) and 896 (64%) were men. Any complications occurred in 397 patients (28%), and surgical complications occurred in 235 patients (17%). Of 1237 patients with an anastomosis, 67 (5%) experienced anastomotic leakage. Higher dietary fiber intake (per 10 g per day) was associated with a lower risk of any complications (odds ratio [OR], 0.75; 95% CI, 0.62-0.92) and surgical complications (OR, 0.76; 95% CI, 0.60-0.97), whereas no association with anastomotic leakage was found (OR, 0.97; 95% CI, 0.66-1.43). Among women, higher dietary intake was associated with any complications (OR, 0.64; 95% CI, 0.44-0.94), whereas there was no association among men (OR, 0.79; 95% CI, 0.63-1.01). Fiber intake from vegetables (per 1 g per day) was inversely associated with any (OR, 0.90; 95% CI, 0.83-0.99) and surgical (OR, 0.87; 95% CI, 0.78-0.97) complications.

Conclusions and Relevance

In this cohort study, higher habitual dietary fiber intake before surgery was associated with a lower risk of postoperative complications among patients with colorectal cancer. The findings suggest that improving preoperative dietary fiber intake may be considered in future prehabilitation programs for patients undergoing surgery for colorectal cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
悠悠完成签到 ,获得积分10
刚刚
人不犯二枉少年完成签到,获得积分10
1秒前
1秒前
研友_Lw7MKL完成签到,获得积分10
1秒前
Alan完成签到,获得积分10
2秒前
葳葳发布了新的文献求助10
2秒前
2秒前
4秒前
4秒前
在险峰发布了新的文献求助10
5秒前
正直的沛凝完成签到,获得积分10
5秒前
6秒前
7秒前
海鸥完成签到,获得积分10
7秒前
蒋若风完成签到,获得积分10
7秒前
爆米花应助孙文杰采纳,获得10
8秒前
小艾完成签到,获得积分10
8秒前
明理萃完成签到 ,获得积分10
9秒前
苏黎世发布了新的文献求助10
9秒前
10秒前
乔安发布了新的文献求助10
10秒前
炫哥IRIS发布了新的文献求助10
10秒前
LaTeXer给积极行天的求助进行了留言
11秒前
ww发布了新的文献求助10
11秒前
Carlo完成签到,获得积分10
12秒前
蓝胖子完成签到 ,获得积分10
13秒前
14秒前
终生科研徒刑完成签到 ,获得积分10
14秒前
15秒前
ysc发布了新的文献求助20
17秒前
18秒前
LKX完成签到 ,获得积分10
18秒前
纯真的诗兰完成签到,获得积分10
19秒前
自然函完成签到 ,获得积分10
19秒前
等一个晴天完成签到,获得积分10
20秒前
as发布了新的文献求助100
20秒前
天天快乐应助科研通管家采纳,获得10
20秒前
研友_VZG7GZ应助科研通管家采纳,获得10
20秒前
个性元枫应助科研通管家采纳,获得10
20秒前
kingwill应助科研通管家采纳,获得20
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048