Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model

热休克蛋白90 计算机科学 医学 生物信息学 生物 遗传学 基因 热休克蛋白
作者
Yuan Xie,Lu Chen,Zhipeng Xu,Chen Li,Yangyue Ni,Min Hou,Lin Chen,Hao Chang,Yuxuan Yang,Huiquan Wang,Rongbo He,Rourou Chen,Lijun Qian,Yan Luo,Ying Zhang,Na Li,Yuxiao Zhu,Minjun Ji,Yu Liu
出处
期刊:Frontiers in Endocrinology [Frontiers Media]
卷期号:12 被引量:9
标识
DOI:10.3389/fendo.2021.743202
摘要

Background and Aims The heat shock protein (Hsp) 90α is induced by stress and regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also called teprenone) is a terpenoid derivative. It was reported to induce Hsp and alleviate insulin resistance. We aimed to evaluate the Hsp90α as a biomarker in predicting metabolic-associated fatty liver disease (MAFLD) and define the therapeutic effects of geranylgeranylacetone for the disease. Methods A clinical study was conducted to analyze the elements associated with Hsp90α, and a predictive model of MAFLD was developed based on Hsp90α. The histopathological correlation between Hsp90α and MAFLD was investigated through a diet-induced mouse model. Furthermore, GGA was applied to the mouse model. Results Serum Hsp90α was increased in patients with MAFLD. A positive linear relationship was found between age, glycosylated hemoglobin (HbA1c), MAFLD, and serum Hsp90α. Meanwhile, a negative linear relationship with body mass index (BMI) was found. A model using Hsp90α, BMI, HbA1c, and ALT was established for predicting MAFLD. The area under the receiver operating characteristic (ROC) curves was 0.94 (95% CI 0.909–0.971, p = 0.000). The sensitivity was 84.1%, and the specificity was 93.1%. In vitro experiments, GGA induced Hsp90α in steatosis cells. In the mice model, Hsp90α decreased in the GGA treatment group. Hepatic steatosis, inflammation, insulin resistance, and glucose intolerance were improved in the GGA-treated group. Serum Hsp90α was positively correlated with steatohepatitis activity according to hepatic histopathology. Conclusions Serum Hsp90α was elevated in MAFLD, and a positive correlation between serum Hsp90α and the grade of activity of steatohepatitis was observed. The model using BMI, HbA1c, and alanine aminotransferase (ALT) had a good value to predict MAFLD. The findings also revealed the effectiveness of GGA in the treatment of MAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
斯文的慕儿完成签到 ,获得积分10
3秒前
keen完成签到 ,获得积分10
3秒前
韭菜盒子完成签到,获得积分20
4秒前
潘特完成签到,获得积分10
5秒前
小彭友完成签到,获得积分10
16秒前
17秒前
josie完成签到 ,获得积分10
21秒前
llll完成签到 ,获得积分10
21秒前
量子星尘发布了新的文献求助10
21秒前
韭菜发布了新的文献求助10
21秒前
外向的斑马完成签到 ,获得积分10
22秒前
村长热爱美丽完成签到 ,获得积分10
24秒前
尹尹关注了科研通微信公众号
26秒前
呆呆完成签到 ,获得积分10
27秒前
xianyaoz完成签到 ,获得积分0
34秒前
杨远杰完成签到,获得积分10
35秒前
蓝桉完成签到 ,获得积分10
35秒前
JuliaWang完成签到 ,获得积分10
42秒前
无限的含羞草完成签到,获得积分10
43秒前
八二力完成签到 ,获得积分10
47秒前
韭菜发布了新的文献求助10
50秒前
情怀应助科研通管家采纳,获得30
53秒前
water应助科研通管家采纳,获得10
53秒前
JamesPei应助科研通管家采纳,获得10
53秒前
2012csc完成签到 ,获得积分0
55秒前
风清扬应助韭菜采纳,获得10
56秒前
WSY完成签到 ,获得积分10
57秒前
虞无声发布了新的文献求助10
58秒前
执着新蕾完成签到,获得积分10
1分钟前
Vivian完成签到 ,获得积分10
1分钟前
666完成签到 ,获得积分10
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
蔡从安完成签到,获得积分10
1分钟前
奥雷里亚诺完成签到 ,获得积分10
1分钟前
不呆完成签到 ,获得积分10
1分钟前
Cheung2121发布了新的文献求助30
1分钟前
画龙完成签到,获得积分10
1分钟前
韭菜完成签到,获得积分20
1分钟前
Owen应助Cheung2121采纳,获得10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038112
求助须知:如何正确求助?哪些是违规求助? 3575788
关于积分的说明 11373801
捐赠科研通 3305604
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022