α1-Antitrypsin A treatment attenuates neutrophil elastase accumulation and enhances insulin sensitivity in adipose tissue of mice fed a high-fat diet
胰岛素抵抗
弹性蛋白酶
医学
胰岛素
作者
Randall F. D'Souza,Stewart W. C. Masson,Jonathan S. T. Woodhead,Samuel L. James,Caitlin MacRae,Christopher P. Hedges,Troy L. Merry
出处
期刊:American Journal of Physiology-endocrinology and Metabolism [American Physiological Society] 日期:2021-09-06卷期号:321 (4)
标识
DOI:10.1152/ajpendo.00181.2021
摘要
Neutrophils accumulate in peripheral tissues during obesity and are critical coordinators of tissue inflammatory responses. Here, we provide evidence that inhibition of the primary neutrophil prote...