药物输送
共价键
组合化学
材料科学
化学
异构化
腙
纳米技术
有机化学
催化作用
作者
Wenjuan Zhao,Chengyang Yu,Jie Zhao,Fengqian Chen,Xinyu Guan,Hui Li,Bin Tang,Guangtao Yu,Valentin Valtchev,Yushan Yan,Shilun Qiu,Qianrong Fang
出处
期刊:Small
[Wiley]
日期:2021-09-12
卷期号:17 (41)
被引量:38
标识
DOI:10.1002/smll.202102630
摘要
Abstract The property expansion of 3D functionalized covalent organic frameworks (COFs) is important for developing their potential applications. Herein, the first case of 3D hydrazone‐decorated COFs as pH‐triggered molecular switches is reported, and their application in the stimuli‐responsive drug delivery system is explored. These functionalized COFs with hydrazone groups on the channel walls are obtained via a multi‐component bottom–up synthesis strategy. They exhibit a reversible E / Z isomerization at various pH values, confirmed by UV–vis absorption spectroscopy and proton conduction. Remarkably, after loading cytarabine (Ara‐C) as a model drug molecule, these pH‐responsive COFs show an excellent and intelligent sustained‐release effect with an almost fourfold increase in the Ara‐C release at pH = 4.8 than at pH = 7.4, which will effectively improve drug‐targeting. Thus, these results open a way toward designing 3D stimuli‐responsive functionalized COF materials and promote their potential application as drug carriers in the field of disease treatment.
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