对映选择合成
化学
立体选择性
烯烃纤维
组合化学
烷基
催化作用
立体化学
有机化学
作者
Matteo Costantini,Abraham Mendoza
出处
期刊:ACS Catalysis
日期:2021-10-18
卷期号:11 (21): 13312-13319
被引量:24
标识
DOI:10.1021/acscatal.1c03949
摘要
Chiral cis-cyclopropanes are strained rigid analogues of alkyl chains, whose study and application are limited by their difficult synthesis. A modular approach from olefin materials is enabled by the discovery of the electron donor–acceptor (EDA) interaction between 2-substituted benzothiazolines and N-hydroxyphthalimide esters. These complexes are activated by visible light without photocatalysts, and the benzothiazoline reagent plays a triple role as a photoreductant, a stereoselective hydrogen-atom donor, and a Brønsted acid. Beyond the enantioselective synthesis of cis-cyclopropanes, these results introduce benzothiazolines as accessible and easily tunable self-sensitized photoreductants.
科研通智能强力驱动
Strongly Powered by AbleSci AI