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Salivary mucoepidermoid carcinoma: histological variants, grading systems, CRTC1/3‐MAML2 fusions, and clinicopathological features

粘液表皮样癌 病理 异型性 组织学 唾液腺 医学 分级(工程) 生物 融合基因 基因 遗传学 生态学
作者
Satsuki Nakano,Yoshihide Okumura,Takayuki Murase,Toshitaka Nagao,Kimihide Kusafuka,Makoto Urano,Hidetaka Yamamoto,Satoshi Kano,Kiyoaki Tsukahara,Kenji Okami,Daisuke Kawakita,Toru Nagao,Nobuhiro Hanai,Hiroshi Iwai,Ryo Kawata,Yuichiro Tada,Ken‐ichi Nibu,Hiroshi Inagaki
出处
期刊:Histopathology [Wiley]
卷期号:80 (4): 729-735 被引量:18
标识
DOI:10.1111/his.14586
摘要

To investigate the histological diversity of salivary mucoepidermoid carcinoma (MEC), its clinicopathological features, and its associations with CRTC1/3-MAML2 fusions.Salivary MEC cases (n = 177) were examined for CRTC1/3-MAML2 fusions, histological variants were classified, and tumours were graded according to four different grading systems. Adverse histological features considered to be unusual in MEC were also investigated. Of the 177 MEC cases, 110 were positive for CRTC1/3-MAML2 fusions. The classical variant was the most frequent in the fusion-positive case group, the fusion-negative case group, and the total case group. The clear/oncocytic variant was the second most frequent in the fusion-positive and total case groups. Oncocytic, Warthin-like and spindle variants were seen in the fusion-positive case group only. Clear cell, sclerosing, mucinous and central variants were seen in both the fusion-positive case group and the fusion-negative case group. No case was classified as a ciliated variant, as a mucoacinar variant, or as a high-grade transformation. As compared with the classical variant, non-classical variants were characterised by frequent CRTC1/3-MAML2 fusions and a low clinical stage in all cases. Of the four histological features considered to be unusual in MEC, marked nuclear atypia, frequent mitoses (>10/10 high-power fields) and extensive necrosis were found independently of the fusion status, and were present in 3-5% of all cases. However, none of the cases showed overt keratinisation. On comparison, the Armed Forces Institute of Pathology and modified Healey grading systems downgraded tumours, the Brandwein system upgraded tumours, and the Memorial Sloan Kettering system provided a moderate means of assessment.Recognition of the histological diversity of MEC, its clinicopathological features and its associations with CRTC1/3-MAML2 fusions is helpful for an accurate diagnosis of this carcinoma.
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