医学
冲程(发动机)
血栓
内科学
缺血性中风
胃肠病学
队列
溶栓
心脏病学
缺血
外科
逻辑回归
心肌梗塞
机械工程
工程类
作者
Laura Mechtouff,Thomas Bochaton,Alexandre Paccalet,Claire Crola Da Silva,Marielle Buisson,Camille Amaz,Laurent Derex,Elodie Ong,Yves Berthezène,Nathalie Dufay,Michel Ovize,Nathan Mewton,Tae‐Hee Cho,Norbert Nighoghossian,Omer Eker
标识
DOI:10.1136/neurintsurg-2021-017334
摘要
First-pass effect (FPE) defined as a complete or near-complete reperfusion achieved after a single thrombectomy pass is predictive of favorable outcome in acute ischemic stroke (AIS) patients. We aimed to assess whether admission levels of inflammatory markers are associated with FPE.HIBISCUS-STROKE (CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke) includes AIS patients with large vessel occlusion treated with mechanical thrombectomy following brain MRI. C-reactive protein, interleukin (IL)-6, IL-8, IL-10, monocyte chemoattractant protein-1, soluble tumor necrosis factor receptor I, soluble form suppression of tumorigenicity 2, matrix metalloproteinase-9 (MMP-9), soluble P-selectin, and vascular cellular adhesion molecule-1 were measured in admission sera using an ELISA assay. FPE was defined as a complete or near-complete reperfusion (thrombolysis in cerebral infarction scale (TICI) 2c or 3) after the first pass. A multivariate logistic regression analysis was performed to assess independent factors associated with FPE.A total of 151 patients were included. Among them, 43 (28.5%) patients had FPE. FPE was associated with low admission levels of IL-6, MMP-9, and platelet count, an older age, lack of hypertension, lack of tandem occlusion, a shorter thrombus length, and a reduced procedural time. Following multivariate analysis, a low admission level of IL-6 was associated with FPE (OR 0.66, 95% CI 0.46 to 0.94). Optimal cut-off of IL-6 level for distinguishing FPE from non-FPE was 3.0 pg/mL (sensitivity 92.3%, specificity 42.3%).A lower admission level of IL-6 is associated with FPE.
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