脚手架
神经组织工程
材料科学
神经干细胞
组织工程
再生医学
干细胞
纳米技术
生物医学工程
细胞生物学
生物
工程类
作者
Fang Han,Xun Ma,Yuanxin Zhai,Leisha Cui,Lingyan Yang,Zhanchi Zhu,Ying Hao,Guosheng Cheng
标识
DOI:10.1002/adhm.202100027
摘要
Abstract Electrical stimulation (ES) offers significant advantages in modulating the behavior of stem cells on conductive scaffolds for neural tissue engineering. However, it is necessary to realize wireless ES to avoid the use of external wires in tissues. Thus, herein, a strategy is reported to develop a stem cell scaffold that allows wireless ES. A conductive annular graphene substrate is designed and grown by chemical vapor deposition; this substrate is used as a secondary coil to achieve wireless ES via electromagnetic induction in the presence of a primary coil. The substrate shows excellent biocompatibility for the culture of neural stem cells (NSCs). The results indicate that the applied wireless ES enhances neuronal differentiation, facilitates the formation of neurites, and does not substantially affect the viability and stemness maintenance of NSCs. Collectively, this system provides a strategy for achieving synergy between wireless ES and conductive scaffolds for neural regenerative medicine, which can be further utilized for the regeneration of other tissues.
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