Mechanisms of in vitro controlled release of astaxanthin from starch-based double emulsion carriers

化学 乳状液 动力学 淀粉 色谱法 渗透 化学工程 有机化学 生物化学 物理 量子力学 工程类
作者
Jie Yang,Qiwei Zhou,Zehao Huang,Zhengbiao Gu,Li Cheng,Lizhong Qiu,Yan Hong
出处
期刊:Food Hydrocolloids [Elsevier BV]
卷期号:119: 106837-106837 被引量:34
标识
DOI:10.1016/j.foodhyd.2021.106837
摘要

The aim of the present study was to illuminate the controlled release mechanism of Astaxanthin (AST) from the biocompatible double emulsions fabricated by inexpensive, renewable and biodegradable native starch (SDEs) using a novel two-step emulsification. The storage stability of the four types of AST-loaded SDEs was evaluated. The results indicated that SDEs prepared with a native corn starch concentration of 7 wt% (7% NCS DEs), and a droplet size of approximately 8 μm without stratification, exhibited excellent storage stability for 35 d. The chemical stability of AST remaining for 7% NCS DEs after 35 d was 90%. The AST-loaded SDEs displayed a high encapsulation efficiency (96%). The release of AST-loaded SDEs was <10% for 120 min in simulated gastric fluid. A sustained and slow release was achieved in simulated intestinal fluid. Moreover, several models have been tested to describe the kinetics of AST release, the most suitable being the diffusion-releasing mechanism. Furthermore, the interaction of SDEs and AST was investigated through steady-state fluorescence measurements and the complexing index. As a demonstration, AST was loaded in the SDEs by hydrophobic interaction and amylose-AST complex formation, enabling the regulation of diffusion and permeation phenomena. Thus, the SDEs are promising oral delivery carriers for lipophilic ingredients.
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