丁烯内酯
立体化学
内酯
化学
双环分子
圆二色性
衍生工具(金融)
烟曲霉
绝对构型
生物
微生物学
金融经济学
经济
作者
Mengyi Deng,Xia Chen,Zhengyi Shi,Shuangshuang Xie,Yuben Qiao,Gang Chen,Xiaosheng Tan,Yuanyuan Lu,Changxing Qi,Yonghui Zhang
出处
期刊:Fitoterapia
[Elsevier]
日期:2021-03-20
卷期号:151: 104882-104882
被引量:14
标识
DOI:10.1016/j.fitote.2021.104882
摘要
Six new metabolites, including two diphenolic derivatives (1 and 2), one pseurotin (3), one butenolide derivative (4), one benzopyran (5) and one isochromane lactone (6), together with ten known compounds (7–16) were isolated from an endophytic fungus Aspergillus sp. Their planar structures and absolute configurations were established based on techniques of MS, NMR, IR, UV, [Rh2(OCOCF3)4] complex-induced ECD, quantum chemical electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Structurally, compound 2 represents the first example of diphenolic derivative possessing an unusual 1-oxaspiro[2.4]heptane core bearing a 5/3 bicyclic skeleton; compound 3 represents the first example of pseurotin type natural products that only one hydroxy group is substituted at side chain. In bioassay, compounds 3, 7 and 8 exhibited potential inhibitory effect on the proliferation of anti-CD3/anti-CD28 monoclonal antibodies (mAbs) induced murine T cells, with IC50 values of (7.81 ± 0.71), (8.25 ± 0.78) and (8.84 ± 0.81) μM, respectively.
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