化学
轴手性
芳基
催化作用
轴流压缩机
钯
模块化设计
降冰片烯
组合化学
阿托品
立体化学
有机化学
对映选择合成
热力学
聚合物
物理
烷基
单体
计算机科学
气体压缩机
操作系统
作者
Qianwen Gao,Chenggui Wu,Shuang Deng,Lisha Li,Ze‐Shui Liu,Hua Yu,Jinxiang Ye,Chang Liu,Hong‐Gang Cheng,Hengjiang Cong,Yinchun Jiao,Qianghui Zhou
摘要
Herein, we report a modular and convergent strategy for the assembly of atropisomeric o-terphenyls with 1,2-diaxes via palladium/chiral norbornene cooperative catalysis and axial-to-axial diastereoinduction. Readily available aryl iodides, 2,6-substituted aryl bromides, and potassium aryl trifluoroborates are used as the building blocks, laying the foundation for diversity-oriented synthesis of these scaffolds (46 examples). Other features include the unique axial-to-axial diastereoinduction mode, construction of two axes in a single operation, and step economy. DFT calculations are performed to rationalize the axial-to-axial diastereoinduction process. Synthetic utilities of this method in preparation of atropisomeric oligophenyls, chiral catalysts, and ligands are demonstrated.
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