Kabachnik-Fields Reaction Under Green Conditions – A Critical Overview

Three-component one-pot Kabachnik-Fields condensation of carbonyl compounds with amines and phosphites is perhaps the most exploited reaction for the preparation of structurally diverse -aminophosphonates. Most of the described protocols might be considered to some extent as green ones with solvent-free and microwave-assisted ones being the most effective. Keywords: Phospha-mannich reaction, hydrophosphonylation, green chemistry, catalysis.