Effect of Exercise on Inflammatory Profile of Older Persons: Systematic Review and Meta-Analyses

医学 荟萃分析 内科学 C反应蛋白 肿瘤坏死因子α 炎症 物理疗法 白细胞介素6
作者
Renato Sobral Monteiro-Júnior,Paulo de Tarso Maciel-Pinheiro,Eduardo da Matta Mello Portugal,Luiz Felipe da Silva Figueiredo,Rodrigo Terra,Lara Carneiro,Vinícius Dias Rodrigues,Osvaldo J. M. Nascimento,Andréa Camaz Deslandes,Jerson Laks
出处
期刊:Journal of Physical Activity and Health [Human Kinetics]
卷期号:15 (1): 64-71 被引量:99
标识
DOI:10.1123/jpah.2016-0735
摘要

Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers.The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons.Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect.Seventy-six studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05).Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.
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