mTORC1型
氨基酸
调节器
计算生物学
鉴定(生物学)
主调节器
生物
生物化学
信号转导
细胞生物学
PI3K/AKT/mTOR通路
基因
生态学
转录因子
作者
Rachel L. Wolfson,David M. Sabatini
标识
DOI:10.1016/j.cmet.2017.07.001
摘要
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors. The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.
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