There has been a significant increase in the number of therapies approved for ulcerative colitis (UC) in the last 5 years, specifically with the introduction of the small molecules. Despite this, there is still a treatment gap in UC with substantial rates of primary and secondary nonresponse. 1 Lasa J.S. et al. Lancet Gastroenterol Hepatol. 2022; 7: 161-170 Abstract Full Text Full Text PDF PubMed Scopus (99) Google Scholar One way to investigate this treatment gap is to look at the "net" remission rates in clinical trials defined as the actual percentage of patients enrolled during induction who are in remission at the end of maintenance. We previously reported the "net" remission rates in Crohn's disease clinical trials by using this methodology. 2 Kayal M. et al. Net Remission Rates with Biologic Treatment in Crohn's Disease: A Reappraisal of the Clinical Trial Data. Clin Gastroenterol Hepatol. 2023; 21: 1348-1350 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar Herein, we apply the same per-protocol analysis to the phase 3 randomized clinical trials for biologics and small molecules approved for UC and calculate 1-year net remission rates.