氧化还原
荧光
化学
近红外光谱
自体荧光
体内
荧光寿命成像显微镜
临床前影像学
光化学
生物物理学
无机化学
生物
光学
物理
生物技术
神经科学
作者
Long He,Lin‐Hui He,Shuai Xu,Tian‐Bing Ren,Xingxing Zhang,Zuojia Qin,Xiaobing Zhang,Lin Yuan
标识
DOI:10.1002/anie.202211409
摘要
Abstract The second near‐infrared (NIR‐II) fluorescent imaging shows great potential for deep tissue analysis at high resolution in living body owing to low background autofluorescence and photon scattering. However, reversible monitoring of redox homeostasis using NIR‐II fluorescent imaging remains a challenge due to the lack of appropriate probes. In this study, a series of stable and multifunctional NIR‐II dyes ( NIR‐II Cy3s ) were constructed based on trimethine skeleton. Significantly, introducing the 1,4‐diethyl‐decahydroquinoxaline group to the NIR‐II Cy3s not only effectively increased the wavelength, but also served as an effective response site for HClO, which can be restored by reactive sulfur species (RSS). Based on this, NIR‐II Cy3s were used for reversible monitoring of HClO/RSS‐mediated redox processes in the pathophysiology environment. Finally, NIR‐II Cy3‐988 was successfully utilized for assessment of the redox environments and drug treatment effects in acute inflammation model.
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