Amyloid-Inspired Engineered Multidomain Amphiphilic Injectable Peptide Hydrogel─An Excellent Antibacterial, Angiogenic, and Biocompatible Wound Healing Material

两亲性 生物材料 材料科学 抗菌剂 抗菌肽 纳米技术 生物相容性材料 生物相容性 伤口愈合 化学 生物医学工程 生物化学 生物 医学 有机化学 免疫学 复合材料 冶金 聚合物 共聚物
作者
Nabanita Mukherjee,Satyajit Ghosh,Jayita Sarkar,Rajsekhar Roy,Debabrata Nandi,Surajit Ghosh
出处
期刊:ACS Applied Materials & Interfaces [American Chemical Society]
卷期号:15 (28): 33457-33479 被引量:1
标识
DOI:10.1021/acsami.3c06599
摘要

The ingrained mechanical robustness of amyloids in association with their fine-tunable physicochemical properties results in the rational design and synthesis of tailor-made biomaterials for specific applications. However, the incredible antimicrobial efficacy of these ensembles has largely been overlooked. This research work provides an insight into the interplay between self-assembly and antimicrobial activity of amyloid-derived peptide amphiphiles and thereby establishes a newfangled design principle toward the development of potent antimicrobial materials with superior wound healing efficacy. Apart from the relationship with many neurodegenerative diseases, amyloids are now considered as an important cornerstone of our innate immune response against pathogenic microbes. Impelled by this observation, a class of amphiphilic antimicrobial peptide-based biomaterial has been designed by taking Aβ42 as a template. The designed AMP due to its amphipathic nature undergoes rapid self-assembly to form a biocompatible supramolecular hydrogel network having significant antibacterial as well as wound healing effectivity on both Gram-negative P. aeruginosa and MRSA-infected diabetic wounds via reduced inflammatory response and enhanced angiogenesis. Results suggest that disease-forming amyloids can be used as a blueprint for the fabrication of biomaterial-based antimicrobial therapeutics by fine-tuning both the hydrophobicity of the β-aggregation prone zone as well as membrane interacting cationic residues.
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