黑腹果蝇
神经退行性变
生物
黑腹菌
线粒体
线粒体DNA
模式生物
粒线体疾病
遗传模型
计算生物学
氧化损伤
神经科学
疾病
遗传学
生物信息学
基因
医学
氧化应激
病理
生物化学
作者
Michele Brischigliaro,Erika Fernandez‐Vizarra,Carlo Viscomi
出处
期刊:Biomolecules
[MDPI AG]
日期:2023-02-16
卷期号:13 (2): 378-378
被引量:5
摘要
The fruit fly-i.e., Drosophila melanogaster-has proven to be a very useful model for the understanding of basic physiological processes, such as development or ageing. The availability of straightforward genetic tools that can be used to produce engineered individuals makes this model extremely interesting for the understanding of the mechanisms underlying genetic diseases in physiological models. Mitochondrial diseases are a group of yet-incurable genetic disorders characterized by the malfunction of the oxidative phosphorylation system (OXPHOS), which is the highly conserved energy transformation system present in mitochondria. The generation of D. melanogaster models of mitochondrial disease started relatively recently but has already provided relevant information about the molecular mechanisms and pathological consequences of mitochondrial dysfunction. Here, we provide an overview of such models and highlight the relevance of D. melanogaster as a model to study mitochondrial disorders.
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