伤口愈合
脚手架
材料科学
3D生物打印
生物医学工程
原位
化学
组织工程
医学
外科
有机化学
作者
Xiaoya Ding,Yunru Yu,Wenzhao Li,Yuanjin Zhao
出处
期刊:Matter
[Elsevier]
日期:2023-03-01
卷期号:6 (3): 1000-1014
被引量:35
标识
DOI:10.1016/j.matt.2023.01.001
摘要
Dynamic hydrogels have been proved valuable in tissue engineering and wound healing, but improving the functionality of these hydrogels without introducing active substances for adapting to the complex chronic wound environment is still challenging. Herein, we present an MoS2 accelerated gelling hydrogel scaffold via in situ three-dimensional (3D) bioprinting for promoting chronic diabetic wound healing. The simple mixing of benzaldehyde and cyanoacetate group-functionalized dextran solutions with MoS2 nanosheets would lead to the ultrafast formation of the hydrogel, which inspired us to employ the mixture as a microfluidic 3D-bioprinting ink. Besides, the printed MoS2 hydrogel scaffold exhibited antioxidant and photothermal antibacterial properties owing to the existence of MoS2 nanosheets. Thus, by directly printing the scaffold in the chronic diabetic wounds, we observed accelerated wound healing with promoted wound closure, alleviated oxidative stress, and eliminated bacterial infection. These indicated that the MoS2 accelerated gelling hydrogel scaffolds are valuable for chronic wound management.
科研通智能强力驱动
Strongly Powered by AbleSci AI