药物发现
计算生物学
生物
细胞色素P450
功能(生物学)
药物开发
酶
生物信息学
药品
生物化学
药理学
细胞生物学
作者
Manzhen Zhou,Junda Li,Jinyi Xu,Lufeng Zheng,Shengtao Xu
标识
DOI:10.1016/j.drudis.2023.103560
摘要
The cytochrome P450 (CYP)4 family of enzymes are monooxygenases responsible for the ω-oxidation of endogenous fatty acids and eicosanoids and play a crucial part in regulating numerous eicosanoid signaling pathways. Recently, CYP4 gained attention as a potential therapeutic target for several human diseases, including cancer, cardiovascular diseases and inflammation. Small-molecule inhibitors of CYP4 could provide promising treatments for these diseases. The aim of the present review is to highlight the advances in the field of CYP4, discussing the physiology and pathology of the CYP4 family and compiling CYP4 inhibitors into groups based on their chemical classes to provide clues for the future discovery of drug candidates targeting CYP4.
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