Emerging metal doped carbon dots for promising theranostic applications

Abstract As a bridge between organic fluorophores and inorganic quantum dots, carbon dots (CDs) have been recognized as emerging nanotheranostics for biomedical applications owing to their distinctive merits such as superior optical properties, flexible modification, adjustable functionalities, and remarkable photoactive therapeutic outcome, etc. Compared to metal free CDs, the introduction of metal ion in CDs endowed metal-doped CDs (MCDs) with tunable optical properties and new intrinsic properties, thereby illustrating its different capabilities from metal-free CDs for bioimaging and therapy. This review aims to summarize the recent progress of photonic MCDs as emerging nanoagent for theranostic application such as disease-related diagnostic (involving biosensing and bioimaging) and cancer therapy. The challenges and potential development of MCDs in nanotheranostic fields are also discussed.