Morphological and molecular characterization of colorectal sessile serrated lesions with dysplasia

发育不良 克拉斯 PDGFRA公司 病理 PTEN公司 增生性息肉 神经母细胞瘤RAS病毒癌基因同源物 结直肠癌 医学 生物 癌症研究 癌症 内科学 遗传学 结肠镜检查 PI3K/AKT/mTOR通路 细胞凋亡 主旨 间质细胞
作者
Filippo Cappello,Valentina Angerilli,Luca Dal Santo,Giada Munari,Marianna Sabbadin,Marcello Mele,Gianmaria Pennelli,Claudio Luchini,Paola Parente,Stefano Lazzi,Matteo Fassan
出处
期刊:Pathology Research and Practice [Elsevier BV]
卷期号:240: 154214-154214
标识
DOI:10.1016/j.prp.2022.154214
摘要

In sessile serrated lesions (SSLs) with adenomatous dysplasia, the dysplastic component and the serrated component without dysplasia should be considered as part of the same lesion, classified as SSL with dysplasia. However, some of these lesions may actually represent collisions between a serrated polyp and a conventional adenoma. Further supporting the "collision theory", conventional adenomatous dysplasia may be found in association with hyperplastic polyps (HPs). In order to determine the molecular and biological landscape of conventional type dysplasia in serrated lesions, we collected 17 cases of colorectal serrated lesions with adenomatous dysplasia, classifying them as SSL with dysplasia (n = 10) or as mixed lesions comprising a HP component and a conventional adenomatous component (n = 7). We characterized the dysplastic and the non-dysplastic component of each lesion, after microdissection, through the targeted mutational analysis of 11 commonly altered genes in colorectal cancer (AKT1, APC, BRAF, CTNNB1, KIT, KRAS, NRAS, PDGFRA, PIK3CA, PTEN and TP53). We also characterized MMR and p53 status by immunohistochemistry. Overall, 14/17 (82.4 %) cases harbored a mutation in at least one of the two components. The most altered genes were BRAF in 10/17 (58.8 %) cases, APC in 2/17 (11.8 %) and TP53 in 4/17 (23.5 %). Among the SSL with dysplasia, the mutational profile was concordant between the two components in 7/10 (70 %) cases, while among the mixed lesions, the mutational profile was concordant in 1/7 (14.3 %). In all but two cases of SSL with dysplasia, MMR status was concordant between the two components of the serrated lesions. Our findings suggest that adenomatous dysplasia may develop in SSL as part of the serrated lesion, even if some SSL with dysplasia may actually be collision lesions. On the other hand, the polyps that are morphologically classifiable as mixed lesions composed of a HP and a conventional adenomatous component are more likely to be collision lesions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sisyphus完成签到,获得积分10
1秒前
SilvanYang应助负责的调料汁采纳,获得10
1秒前
2秒前
JamesPei应助zs采纳,获得10
2秒前
2秒前
悦耳的尔冬完成签到,获得积分20
3秒前
ddy完成签到,获得积分10
3秒前
紫薯球完成签到,获得积分10
3秒前
5秒前
Kiling完成签到,获得积分20
5秒前
Passerby完成签到,获得积分10
7秒前
猪猪侠完成签到,获得积分10
9秒前
张小北发布了新的文献求助10
10秒前
10秒前
10秒前
量子星尘发布了新的文献求助10
11秒前
11秒前
Ava应助衡阳采纳,获得10
12秒前
zzf完成签到,获得积分10
12秒前
慵懒芙芙完成签到 ,获得积分10
12秒前
粽子完成签到,获得积分10
13秒前
13秒前
zs发布了新的文献求助10
14秒前
烟花应助111采纳,获得10
15秒前
向日繁花发布了新的文献求助10
15秒前
15秒前
16秒前
tang应助王才强采纳,获得10
16秒前
小马甲应助12214采纳,获得10
17秒前
Acetonitrile完成签到,获得积分10
18秒前
桐桐应助忧心的不二采纳,获得10
19秒前
20秒前
lxiaok完成签到,获得积分10
20秒前
刻苦的元风完成签到,获得积分10
21秒前
Rondab应助蓝莓松饼采纳,获得10
21秒前
21秒前
22秒前
22秒前
tetrakis发布了新的文献求助10
23秒前
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970008
求助须知:如何正确求助?哪些是违规求助? 3514711
关于积分的说明 11175563
捐赠科研通 3250077
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804931