Morphological and molecular characterization of colorectal sessile serrated lesions with dysplasia

发育不良 克拉斯 PDGFRA公司 病理 PTEN公司 增生性息肉 神经母细胞瘤RAS病毒癌基因同源物 结直肠癌 医学 生物 癌症研究 癌症 内科学 遗传学 结肠镜检查 PI3K/AKT/mTOR通路 细胞凋亡 主旨 间质细胞
作者
Filippo Cappello,Valentina Angerilli,Luca Dal Santo,Giada Munari,Marianna Sabbadin,Marcello Mele,Gianmaria Pennelli,Claudio Luchini,Paola Parente,Stefano Lazzi,Matteo Fassan
出处
期刊:Pathology Research and Practice [Elsevier BV]
卷期号:240: 154214-154214
标识
DOI:10.1016/j.prp.2022.154214
摘要

In sessile serrated lesions (SSLs) with adenomatous dysplasia, the dysplastic component and the serrated component without dysplasia should be considered as part of the same lesion, classified as SSL with dysplasia. However, some of these lesions may actually represent collisions between a serrated polyp and a conventional adenoma. Further supporting the "collision theory", conventional adenomatous dysplasia may be found in association with hyperplastic polyps (HPs). In order to determine the molecular and biological landscape of conventional type dysplasia in serrated lesions, we collected 17 cases of colorectal serrated lesions with adenomatous dysplasia, classifying them as SSL with dysplasia (n = 10) or as mixed lesions comprising a HP component and a conventional adenomatous component (n = 7). We characterized the dysplastic and the non-dysplastic component of each lesion, after microdissection, through the targeted mutational analysis of 11 commonly altered genes in colorectal cancer (AKT1, APC, BRAF, CTNNB1, KIT, KRAS, NRAS, PDGFRA, PIK3CA, PTEN and TP53). We also characterized MMR and p53 status by immunohistochemistry. Overall, 14/17 (82.4 %) cases harbored a mutation in at least one of the two components. The most altered genes were BRAF in 10/17 (58.8 %) cases, APC in 2/17 (11.8 %) and TP53 in 4/17 (23.5 %). Among the SSL with dysplasia, the mutational profile was concordant between the two components in 7/10 (70 %) cases, while among the mixed lesions, the mutational profile was concordant in 1/7 (14.3 %). In all but two cases of SSL with dysplasia, MMR status was concordant between the two components of the serrated lesions. Our findings suggest that adenomatous dysplasia may develop in SSL as part of the serrated lesion, even if some SSL with dysplasia may actually be collision lesions. On the other hand, the polyps that are morphologically classifiable as mixed lesions composed of a HP and a conventional adenomatous component are more likely to be collision lesions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
sunny心晴完成签到 ,获得积分10
2秒前
独特的凝云完成签到 ,获得积分10
2秒前
TheDing完成签到,获得积分10
3秒前
传奇3应助lenetivy采纳,获得10
5秒前
积极的忆曼完成签到,获得积分10
6秒前
量子星尘发布了新的文献求助10
6秒前
酒剑仙完成签到,获得积分10
6秒前
YANGMJ完成签到,获得积分10
7秒前
xialuoke完成签到,获得积分10
7秒前
scinature发布了新的文献求助10
8秒前
8秒前
8秒前
小洪俊熙完成签到,获得积分10
10秒前
狄百招完成签到 ,获得积分10
10秒前
UU完成签到,获得积分10
11秒前
半夏完成签到,获得积分10
13秒前
Judy完成签到 ,获得积分10
13秒前
跳跳糖完成签到,获得积分10
14秒前
JS完成签到,获得积分10
15秒前
胡萝卜完成签到,获得积分10
16秒前
Hunter完成签到,获得积分10
16秒前
耍酷依玉完成签到,获得积分10
16秒前
luo完成签到,获得积分10
17秒前
大橙子发布了新的文献求助10
18秒前
唯爱薇儿完成签到,获得积分10
19秒前
scinature完成签到,获得积分10
19秒前
20秒前
SilverPlane完成签到,获得积分10
20秒前
ATOM完成签到,获得积分10
21秒前
宫跃然完成签到,获得积分10
21秒前
sciforce完成签到,获得积分10
22秒前
刻苦的黑米完成签到,获得积分10
24秒前
24秒前
songvv发布了新的文献求助10
24秒前
欢喜大白菜真实的钥匙完成签到 ,获得积分10
24秒前
小石头完成签到,获得积分10
25秒前
Wguan完成签到,获得积分10
25秒前
zgt01发布了新的文献求助10
26秒前
白夜完成签到 ,获得积分10
30秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022