伤口愈合
细胞外基质
成纤维细胞
生物材料
再生(生物学)
细胞粘附
纳米技术
焦点粘着
粘附
细胞迁移
材料科学
化学
细胞
生物物理学
细胞生物学
免疫学
生物
生物化学
复合材料
体外
作者
Ruoyan Sun,Xinyu Jin,Yuying Bao,Zhanshuo Cao,Dong Gao,Ran Zhang,Liang Qiu,Hongbo Yuan,Chengfen Xing
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-03-01
卷期号:24 (10): 3257-3266
被引量:1
标识
DOI:10.1021/acs.nanolett.4c00307
摘要
The extracellular matrix (ECM) orchestrates cell behavior and tissue regeneration by modulating biochemical and mechanical signals. Manipulating cell-material interactions is crucial for leveraging biomaterials to regulate cell functions. Yet, integrating multiple cues in a single material remains a challenge. Here, near-infrared (NIR)-controlled multifunctional hydrogel platforms, named PIC/CM@NPs, are introduced to dictate fibroblast behavior during wound healing by tuning the matrix oxidative stress and mechanical tensions. PIC/CM@NPs are prepared through cell adhesion-medicated assembly of collagen-like polyisocyanide (PIC) polymers and cell-membrane-coated conjugated polymer nanoparticles (CM@NPs), which closely mimic the fibrous structure and nonlinear mechanics of ECM. Upon NIR stimulation, PIC/CM@NPs composites enhance fibroblast cell proliferation, migration, cytokine production, and myofibroblast activation, crucial for wound closure. Moreover, they exhibit effective and toxin removal antibacterial properties, reducing inflammation. This multifunctional approach accelerates healing by 95%, highlighting the importance of integrating biochemical and biophysical cues in the biomaterial design for advanced tissue regeneration.
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