Association of exposure factors and their causal relationship with oral cancer: A Mendelian randomization study

孟德尔随机化 医学 因果关系(物理学) 观察研究 环境卫生 癌症 酒精摄入量 风险因素 癌症预防 内科学 生物 基因型 遗传学 生物化学 物理 量子力学 遗传变异 基因
作者
Yunyao Li,Kang Wang,Xiaobing Li,Linqian Zhang
出处
期刊:Research Square - Research Square
标识
DOI:10.21203/rs.3.rs-3714852/v1
摘要

Abstract Objectives There is a strong association among risk factors for oral cancer (ORCA), such as smoking, alcohol consumption, fiber intake, and red meat intake. The apparent synergistic effects reported in previous observational studies may also underestimate the independent effects.Our study aims to further explore the potential etiology and causality of oral cancer. Materials and Methods This study used the genome-wide association studies database (GWAS) for Mendelian randomization (MR) analysis to explore exposure factors associated with ORCA and detect the genetic causality between these exposures and ORCA risk. Results Our results demonstrated that in univariate MR analysis, the five exposure factors (celery intake, average weekly beer and cider intake, spirits intake, and pork intake) were risk factors, and oily fish intake was a safety factor, but in multivariate MR analysis, pork intake had the greatest impact on oral cancer when the five food/drink intakes were simultaneously consumed. Conclusions The causal relationship between the five exposure factors (oily fish intake, celery intake, pork intake, average weekly beer and cider intake, and spirits intake) and oral cancer was analyzed. The causal effects of pork on oral cancer may be underestimated. Clinical Relevance Prevention of oral cancer requires better education about lifestyle-related risk factors, and improved awareness and tools for early diagnosis. Our study provides some risk factors that cannot be ignored for the cause prevention of oral cancer, such as pork intake, and its role in oral cancer prevention and control.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
thchiang完成签到 ,获得积分10
刚刚
面壁思过应助圈圈叉叉采纳,获得10
1秒前
CHB只争朝夕完成签到 ,获得积分10
1秒前
安超楷完成签到,获得积分10
1秒前
开放觅夏发布了新的文献求助30
2秒前
3秒前
6秒前
7秒前
开放觅夏完成签到,获得积分10
7秒前
热情凝云完成签到,获得积分10
10秒前
探寻发布了新的文献求助10
10秒前
甘博发布了新的文献求助10
10秒前
我是老大应助AURORA98采纳,获得10
11秒前
飘逸小懒猪应助AURORA98采纳,获得50
11秒前
所所应助AURORA98采纳,获得10
11秒前
jyy应助AURORA98采纳,获得50
11秒前
11秒前
xinxin发布了新的文献求助10
14秒前
14秒前
15秒前
小鱼完成签到,获得积分20
16秒前
16秒前
CodeCraft应助sbw采纳,获得10
17秒前
零一发布了新的文献求助10
21秒前
xinxin完成签到,获得积分10
21秒前
桑叶发布了新的文献求助10
21秒前
量子星尘发布了新的文献求助10
21秒前
傲娇衬衫发布了新的文献求助10
22秒前
Hello应助友好驳采纳,获得10
24秒前
阿桂发布了新的文献求助10
25秒前
26秒前
27秒前
Longfenzhong完成签到,获得积分10
27秒前
零一完成签到,获得积分10
27秒前
breaddog完成签到,获得积分10
28秒前
思源应助实验顺顺利利采纳,获得10
29秒前
迅速孤容完成签到 ,获得积分10
30秒前
30秒前
桑叶完成签到 ,获得积分10
30秒前
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403