Association of exposure factors and their causal relationship with oral cancer: A Mendelian randomization study

孟德尔随机化 医学 因果关系(物理学) 观察研究 环境卫生 癌症 酒精摄入量 风险因素 癌症预防 内科学 生物 基因型 遗传学 生物化学 物理 量子力学 遗传变异 基因
作者
Yunyao Li,Kang Wang,Xiaobing Li,Linqian Zhang
出处
期刊:Research Square - Research Square
标识
DOI:10.21203/rs.3.rs-3714852/v1
摘要

Abstract Objectives There is a strong association among risk factors for oral cancer (ORCA), such as smoking, alcohol consumption, fiber intake, and red meat intake. The apparent synergistic effects reported in previous observational studies may also underestimate the independent effects.Our study aims to further explore the potential etiology and causality of oral cancer. Materials and Methods This study used the genome-wide association studies database (GWAS) for Mendelian randomization (MR) analysis to explore exposure factors associated with ORCA and detect the genetic causality between these exposures and ORCA risk. Results Our results demonstrated that in univariate MR analysis, the five exposure factors (celery intake, average weekly beer and cider intake, spirits intake, and pork intake) were risk factors, and oily fish intake was a safety factor, but in multivariate MR analysis, pork intake had the greatest impact on oral cancer when the five food/drink intakes were simultaneously consumed. Conclusions The causal relationship between the five exposure factors (oily fish intake, celery intake, pork intake, average weekly beer and cider intake, and spirits intake) and oral cancer was analyzed. The causal effects of pork on oral cancer may be underestimated. Clinical Relevance Prevention of oral cancer requires better education about lifestyle-related risk factors, and improved awareness and tools for early diagnosis. Our study provides some risk factors that cannot be ignored for the cause prevention of oral cancer, such as pork intake, and its role in oral cancer prevention and control.
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