The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry

主旨 医学 外科肿瘤学 辅助治疗 间质瘤 腹部外科 佐剂 内科学 肿瘤科 普通外科 间质细胞 癌症
作者
Ryugo Teranishi,Tsuyoshi Takahashi,Shinsuke Sato,Katsunobu Sakurai,Kentaro Kutsukake,Hisahiro Hosogi,Toshiko Nakai,Yukinori Kurokawa,Junya Fujita,Toshirou Nishida,Seiichi Hirota,Toshimasa Tsujinaka
出处
期刊:Gastric Cancer [Springer Science+Business Media]
卷期号:27 (2): 355-365
标识
DOI:10.1007/s10120-023-01444-8
摘要

Abstract Introduction Contour maps enable risk classification of GIST recurrence in individual patients within 10 postoperative years. Although contour maps have been referred to in Japanese guidelines, their usefulness and role in determining indications for adjuvant therapy is still unclear in Japanese patients. The aims of this study are to investigate the validity of contour maps in Japanese patients with GIST and explore the new strategy for adjuvant therapy. Materials and methods A total of 1426 Japanese GIST patients who were registered to the registry by the Kinki GIST Study Group between 2003 and 2012 were analyzed. Patients who had R0 surgery without perioperative therapy were included in this study. The accuracy of contour maps was validated. Results Overall, 994 patients have concluded this study. Using contour maps, we validated the patients. The 5-year recurrence-free survival rates of patients within the GIST classification groups of 0–10%, 10–20%, 20–40%, 40–60%, 60–80%, 80–90%, and 90–100% were 98.1%, 96.6%, 92.3%, 48.0%, 37.3%, 41.0% and 42.4%, respectively. We confirmed that this classification by contour maps was well reflected recurrence prediction. Further, in the high-risk group stratified by the modified National Institutes of Health consensus criteria (m-NIHC), the 10-year RFS rate was remarkably changed at a cutoff of 40% (0–40% group vs. 40–100% group: 88.7% vs. 50.3%, p < 0.001). Conclusion Contour maps are effective in predicting individual recurrence rates. And it may be useful for the decision of individual strategy for high-risk patients combined with m-NIHC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助豆豆采纳,获得10
刚刚
1秒前
您的帮助将会点亮世界完成签到,获得积分10
1秒前
2秒前
yar应助lcy采纳,获得10
2秒前
要减肥的香芦完成签到,获得积分10
3秒前
hunbaekkkkk完成签到 ,获得积分10
4秒前
qiu完成签到,获得积分10
4秒前
十一发布了新的文献求助10
5秒前
5秒前
5秒前
wocala发布了新的文献求助30
5秒前
今后应助辛辛采纳,获得10
5秒前
6秒前
7秒前
zxy发布了新的文献求助10
7秒前
科研通AI2S应助Suen采纳,获得10
7秒前
乐乐应助fff采纳,获得10
8秒前
9秒前
SIiveryyyy发布了新的文献求助10
9秒前
完美世界应助Vincenzo采纳,获得10
9秒前
wanci应助1147468624采纳,获得10
9秒前
传奇3应助自觉的夏蓉采纳,获得10
11秒前
11秒前
阔达金鱼完成签到,获得积分10
11秒前
又又发布了新的文献求助10
11秒前
wjx发布了新的文献求助10
11秒前
not完成签到,获得积分10
12秒前
各位大牛帮帮忙完成签到,获得积分10
12秒前
Tinmuse发布了新的文献求助10
14秒前
邹醉蓝完成签到,获得积分0
14秒前
14秒前
大地发布了新的文献求助10
14秒前
15秒前
快乐柴柴发布了新的文献求助10
16秒前
16秒前
16秒前
17秒前
17秒前
铁手无情完成签到,获得积分10
17秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974844
求助须知:如何正确求助?哪些是违规求助? 3519270
关于积分的说明 11197844
捐赠科研通 3255496
什么是DOI,文献DOI怎么找? 1797791
邀请新用户注册赠送积分活动 877187
科研通“疑难数据库(出版商)”最低求助积分说明 806202