Gait kinematics of osteoarthritic knees after intra-articular viscosupplementation: A double-blinded randomized controlled trial

医学 增粘剂 骨关节炎 矢状面 步态 物理疗法 步态分析 与踏步机 运动学 安慰剂 随机对照试验 物理医学与康复 外科 关节内 解剖 替代医学 病理 物理 经典力学
作者
Leonardo Metsavaht,Gustavo Leporace,Bernardo Crespo,Felipe F. Gonzalez,Marcelo Motta Pereira,Eliane Celina Guadagnin,Jorge Chahla,Carlos Eduardo da Silveira Franciozi,Marcus Vinícius Malheiros Luzo
出处
期刊:Knee [Elsevier BV]
卷期号:47: 102-111 被引量:1
标识
DOI:10.1016/j.knee.2024.01.007
摘要

Background The utilization of subjective questionnaires for assessing conservative treatment in knee osteoarthritis may present challenges in identifying differences due to inadequate statistical power. Objective tools, such as three-dimensional (3D) kinematic analysis, are accurate and reproducible methods. However, no high-quality studies assessing the effects of intra-articular viscosupplementation (VS) have been published. Therefore, the objective of the study was to evaluate gait kinematics of patients with advanced knee osteoarthritis after VS. Methods Forty-two patients were randomized to receive either VS or saline injection (placebo). They underwent 3D kinematic gait analysis before and at 1, 6, and 12 weeks after treatment and knee angles during stance phase were determined. Patients and the healthcare team responsible for data collection, processing, and analysis were blinded to group allocation. Between-group comparisons were conducted using linear mixed models. Results Compared with placebo, the VS increased the maximum knee extension (3.2° (0.7–5.7)) and decreased the maximum knee flexion (-3.6° (−6.1 to −1.2)) on the sagittal plane at 1 week. At 6 weeks, the VS group sustained a reduced maximum knee flexion (−2.6° (−5.2 to 0.0)). On the axial plane, the VS group demonstrated an increase in maximum internal rotation at 12 weeks (3.9° (0.3 to 7.7)). The VS group exhibited reduced single-leg stance time at 1 week and increased total stance time at 12 weeks. Conclusions VS led to short- and long-term kinematic improvements in the sagittal and axial planes, leading to a gait pattern closer to that observed in individuals with less severe osteoarthritic knees.
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