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Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis

医学 乳腺癌 混淆 前列腺癌 结直肠癌 肿瘤科 置信区间 内科学 流行病学 妇科 癌症 人口学 社会学
作者
Nikos Papadimitriou,Nabila Kazmi,Niki Dimou,Konstantinos K. Tsilidis,Richard M. Martin,Sarah Lewis,Brigid M. Lynch,Michael Hoffmeister,Sun‐Seog Kweon,Li Li,Roger L. Milne,Lori C. Sakoda,Robert E. Schoen,Amanda I. Phipps,Jane C. Figueiredo,Ulrike Peters,Suzanne C. Dixon‐Suen,Marc J. Gunter,Neil Murphy
出处
期刊:Cancer Medicine [Wiley]
卷期号:13 (1) 被引量:2
标识
DOI:10.1002/cam4.6732
摘要

Abstract Background Sedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal. Methods We used univariable and multivariable two‐sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self‐reported leisure television watching and computer use were identified from a recent genome‐wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding. Results A 1‐standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1‐SD: 1.15, 95% confidence interval [CI]: 1.05–1.26) and colorectal cancer (OR per 1‐SD: 1.32, 95% CI: 1.16–1.49) while there was little evidence of an association for prostate cancer risk (OR per 1‐SD: 0.94, 95% CI: 0.84–1.06). After adjusting for years of education, the effect estimates for television watching were attenuated (breast cancer, OR per 1‐SD: 1.08, 95% CI: 0.92–1.27; colorectal cancer, OR per 1‐SD: 1.08, 95% CI: 0.90–1.31). Post hoc analyses showed that years of education might have a possible confounding and mediating role in the association between television watching with breast and colorectal cancer. Consistent results were observed for each cancer site according to sex (colorectal cancer), anatomical subsites and cancer subtypes. There was little evidence of associations between genetically predicted computer use and cancer risk. Conclusions Our univariable analysis identified some positive associations between hours of television watching and risks of breast and colorectal cancer. However, further adjustment for additional lifestyle factors especially years of education attenuated these results. Future studies using objective measures of exposure can provide new insights into the possible role of sedentary behaviour in cancer development.
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